Pharmacology Questions (2) for USMLE, MCCEE, PLAB, FCPS, PDMC,MRCP………

A 64 year old woman complains of low back pain for 1 week. Her pain and tenderness is localized over the lumbar spine and exaggerated by movement. Her physician prescribes her a phosphonate drug What is the mechanism of action of this drug for this patient?

  • A- Decrease osteoclast activity
  • B- Increase osteoblast activity
  • C- Decrease parathormone activity
  • D- Increase vitamin D absorption
  • E- Increase urinary calcium reabsorption


This is most likely a case of osteoporosis. Phosphonates improve this condition through decreasing osteoclast activity.

The correct answer is A


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